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(2009) Focus on mammalian thioredoxin reductases important selenoproteins with versatile functions, Biochim

The difference is small on paper but significant in practice

In hypoxic disc environments, hypoxia-inducible factor 1 alpha (HIF-1) activates autophagy pathways, helping to mitigate ROS generation while promoting chondrogenic differentiation and cartilage matrix synthesis [84]

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This culminates in increased excitability at hippocampal Cornu Ammonis (CA1) Schaffer collateral synapses (Perez-Catalan et al., 2021) due to enhanced expression of the -amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor (AMPA receptor/AMPA-R)